NR AJTW
AU Quarmby,J.W.; Engelke,C.; Chitolie,A.; Morgan,R.A.; Belli,A.M.
TI Autologous thrombin for treatment of pseudoaneurysms
QU Lancet 2002 Mar 16; 359(9310): 946-7
PT letter
AB Femoral pseudoaneurysms arise in up to 2% of patients after femoral cannulation for cardiac catheterisation. We used autologous thrombin for percutaneous obliteration of pseudoaneurysms occurring after catheterisation. We prepared autologous thrombin isolates from blood of ten patients with femoral pseudoaneurysms, and injected this solution into the pseudoaneurysms with duplex imaging guidance. We then assayed thrombin activity. All pseudoaneurysms were successfully thrombosed without substantial complications, although three patients needed a repeat procedure within 24 h. We have shown that autologous thrombin-induced thrombosis of pseudoaneurysms is reliable, simple, safe, and cheaper than commercial bovine or human thrombin, and avoids risks of anaphylaxis and contamination with prions.
MH Aneurysm, False/*drug therapy; Female; *Femoral Artery; Human; Male; Middle Age; Thrombin/isolation & purification/*therapeutic use; Treatment Outcome
SP englisch
PO England