NR AJUD
AU Rabinstein,A.A.; Whiteman,M.L.; Shebert,R.T.
TI Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations
QU Archives of Neurology 2002 Apr; 59(4): 637-9
PT journal article
AB BACKGROUND: The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned. OBJECTIVE: To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease. METHODS: Case report. RESULTS: A patient with a history of 3 corneal transplantations exhibited the alien hand sign on initial examination. Diffusion-weighted magnetic resonance imaging of the brain revealed prominent cortical diffusion abnormalities. During the following months, the patient developed rapidly progressive dementia. The diagnosis of Creutzfeldt-Jakob disease was proven by brain biopsy. CONCLUSION: Brain magnetic resonance imaging, particularly diffusion-weighted magnetic resonance imaging, can be very helpful in the diagnosis of Creutzfeldt-Jakob disease, even in suspected iatrogenic cases.
MH Brain/*pathology; Case Report; *Corneal Transplantation; Creutzfeldt-Jakob Syndrome/*diagnosis/pathology; Human; *Magnetic Resonance Imaging/methods; Male; Middle Age; Predictive Value of Tests
AD University of Miami School of Medicine D4-5, PO Box 016960, Miami, FL 33101, USA. alerabas@yahoo.com
SP englisch
PO USA