NR AJWG
AU Rappaport,E.B.; Graham,D.J.
TI Pituitary growth hormone from human cadavers: neurologic disease in ten recipients.
QU Neurology 1987 Jul; 37(7): 1211-3
PT journal article
AB Creutzfeldt-Jakob disease (CJD) has been reported in three US patients previously treated with human growth hormone derived from large pools of human cadaver pituitary glands (pit-hGH). Neurologic disorders other than CJD occurred in 10 growth hormone-deficient patients treated with pit-hGH. These 10 cases could have been chance events or true syndromes; some cases may have been caused by transmissible agents contained in the pooled growth hormone product.
MH Adolescent; Adult; Cadaver; Case Report; Female; Growth Hormone/*adverse effects/deficiency/therapeutic use; Human; Hypopituitarism/drug therapy; Male; Nervous System Diseases/*etiology; Polyradiculoneuropathy/etiology; Spinocerebellar Degenerations/etiology
SP englisch
PO USA