NR AJWH
AU Rasenick,M.M.; Valley,S.; Manuelidis,E.E.; Manuelidis,L.
TI Creutzfeldt-Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain
QU FEBS Letters 1986 Mar 17; 198(1): 164-8
PT journal article
AB Creutzfeldt-Jakob disease is a slow, infectious, progressive neurological disorder which results in human dementia. Synaptic membranes from various brain regions of guinea pigs infected with Creutzfeldt-Jakob disease show increased guanyl nucleotide- or 5-hydroxytryptamine-mediated activation of adenylate cyclase. This increased enzyme activity appears due, primarily, to facilitated 'coupling' between the GTP-binding protein which stimulates adenylate cyclase (GNs) and the catalytic moiety of that enzyme rather than increased sensitivity to 5-hydroxytryptamine. It is possible that this phenomenon is due to direct effects of the Creutzfeldt-Jakob infectious agent, or a pathological product resulting from that agent, upon synaptic membrane adenylate cyclase.
IN Synaptische Membranen in verschiedenen Regionen scrapieinfizierter Meerschweinchen zeigten eine gesteigerte Guanylnukleotid- oder 5-Hydroxytryptamin-vermittelte Aktivierung der Adenylatzyklase. Diese gesteigerte Enzymaktivität scheint primär auf einer erleichterte Kopplung zwischen dem die Adenylatzyklase stimulierenden GTP-bindenden Protein und der katalytischen Einheit der Adenylatzyklase zu beruhen und nicht auf eine gesteigerte Empfindlichkeit für 5-Hydroxytryptamin (Serotonin).
MH Adenylate Cyclase/*analysis; Animal; Brain/*enzymology; Creutzfeldt-Jakob Syndrome/*enzymology; GTP-Binding Proteins/analysis; Guanylyl Imidodiphosphate/pharmacology; Guinea Pigs; Oncogene Proteins, Viral/analysis; Scrapie/enzymology; Serotonin/pharmacology; Sodium Fluoride/pharmacology; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.
SP englisch
PO Niederlande