NR AJWY
AU Redman,C.A.; Coen,P.G.; Matthews,L.; Lewis,R.M.; Dingwall,W.S.; Foster,J.D.; Chase-Topping,M.E.; Hunter,N.; Woolhouse,M.E.J.
TI Comparative epidemiology of scrapie outbreaks in individual sheep flocks
QU Epidemiology and Infection 2002 Jun; 128(3): 513-21
PT journal article
AB Data recording the course of scrapie outbreaks in 4 sheep flocks (2 in Cheviot sheep and 2 in Suffolks) are compared. For each outbreak the data on scrapie incidence and sheep demography and pedigrees cover periods of years or decades. A key finding is that the incidence of clinical cases peaks in sheep 2-3 years old, despite very different forces-of-infection. This is consistent with age-specific susceptibility of sheep to scrapie, as has been reported for cattle to bovine spongiform encephalopathy and for humans to variant Creutzfeldt-Jakob disease. Scrapie incidence was higher in ewes than rams and at certain times of years, though these effects were not consistent between flocks. There was no evidence for high levels of vertical transmission.
MH Age Factors; Animal; Comparative Study; Disease Outbreaks/*veterinary; Female; Incidence; Male; Pedigree; Scrapie/*epidemiology/pathology; Seasons; Sex Factors; Sheep; Support, Non-U.S. Gov't
AD C. A. Redman, P. G. Coen, L. Matthews, M. E. Chase-Topping, M. E. J. Woolhouse, Centre for Tropical Veterinary Medicine, University of Edinburgh, Roslin, Midlothian EH25 9RG, UK; R.M. Lewis, W. S. Dingwall, Animal Biology Di.ision, Scottish Agricultural College, Bush Estate, Penicuik, Midlothian EH26 0PH, UK; J. D. Foster, N. Hunter, Institute for Animal Health Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh, EH9 3JF, UK
SP englisch
PO England