NR AJXH
AU Reiersen,H.; Rees,A.R.
TI The hunchback and its neighbours: proline as an environmental modulator.
QU Trends in Biochemical Sciences 2001 Nov; 26(11): 679-84
PT journal article; review; review, tutorial
AB The unique ability of Pro or Pro-rich repeats to affect the stability and function of proteins has recently been highlighted by biophysical studies on fragments from prions, signalling domains and muscle proteins. Pro-rich regions have been observed to either occupy disordered states or adopt various helical structures; some are also able to undergo an environmental-dependent transformation between these states. Such a transformation could explain some of the inherent functional properties of the parent proteins and, additionally, can be efficiently exploited to generate novel temperature- and pH-switches in more conventional globular proteins.
ZR 56
MH Amino Acid Sequence; Animal; Binding Sites; Environment; Genetic Engineering; Human; Models, Molecular; Peptides/*chemistry/*physiology; Prions/chemistry; Protein Conformation; Support, Non-U.S. Gov't
AD Affitech AS, Oslo Research Park, Gaustadalleen 21, N-0349, Oslo, Norway.
SP englisch
PO England