NR AJXQ
AU Renkawek,K.; de Jong,W.W.; Merck,K.B.; Frenken,C.W.G.M.; van Workum,F.P.A.; Bosman,G.J.C.G.M.
TI alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease
QU Acta Neuropathologica 1992; 83(3): 324-7
PT journal article
AB alpha-Crystallin is a major eye lens protein, composed of two types of subunits, alpha A and alpha B. The alpha A subunit is restricted to the lens, but alpha B-crystallin has recently also been detected in non-lenticular tissues, including the nervous system. With the use of a polyclonal antiserum directed against a synthetic C-terminal peptide of human alpha B-crystallin, the presence of alpha B-crystallin could be demonstrated immunohistochemically in astrocytes in the brains of patients with Creutzfeldt-Jakob disease (CJD). Most intensive localization was observed in the spongiotic tissue representing abundant progressively changed astrocytes in CJD. In age-matched control brains weak positive reaction was located in individual oligodendroglia cells and subpial astrocytes. Prominent increase of alpha B-crystallin in pathological glia in CJD may represent a response to stress.
IN Die Expression der nicht auf die Augenlinse beschränkten Untereinheit B des alpha-Crystallins ist bei Creutzfeldt-Jakob-Patienten in den Astrozyten, insbesondere der schwammförmig degenerierten Regionen, verstärkt.
MH Amino Acid Sequence; Brain/metabolism/ultrastructure; Creutzfeldt-Jakob Syndrome/*metabolism/pathology; Crystallins/chemistry/immunology/*metabolism; Epitopes; Human; Immunohistochemistry/methods; Middle Age; Molecular Sequence Data; Neuroglia/*metabolism; Staining and Labeling
AD Institute of Neurology, University Hospital Nijmegen, The Netherlands.
SP englisch
PO Deutschland