NR AJYV
AU Richardson,E.P.Jr.; Masters,C.L.
TI The nosology of Creutzfeldt-Jakob disease and conditions related to the accumulation of PrPcJD in the nervous system
QU Brain Pathology 1995 Jan; 5(1): 33-41
PT historical article; journal article; review; review, tutorial
AB Although typical cases of Creutzfeldt-Jakob disease are readily recognized pathologically and clinically, variant forms often pose a diagnostic challenge. From the 1920's, when this disease was first characterized, until quite recently diagnosis relied heavily on morphologic changes. New advances in immunoassays and PrP gene analysis now provide important adjuncts in recognizing the spectrum of disorders of PrP metabolism associated with these transmissible encephalopathies.
ZR 99
MH Brain/metabolism/*pathology; *Creutzfeldt-Jakob Syndrome/*classification/genetics/history/pathology; DNA Mutational Analysis; Female; Gerstmann-Sträussler-Scheinker Disease/classification/genetics/pathology; History of Medicine, 20th Cent.; Human; Male; PrPsc Proteins/*genetics/metabolism; Prion Diseases/*classification/genetics/history/pathology
AD Charles S Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston 02114-2696, USA
SP englisch
PO Schweiz