NR AKDB
AU Roikhel',V.M.; Fokina,G.I.; Sobolev,S.G.; Korolyev,M.B.; Pogodina,V.V.
TI Effect of hyperbaric oxygenation on experimental scrapie in mice
QU Acta Virologica 1984 Jul; 28(4): 294-9
PT journal article
AB The effect of hyperbaric oxygenation upon experimental infection of BALB/c mice with the scrapie agent was investigated by virological methods, histology and electron microscopy. A multiple exposure of scrapie-infected mice to hyberbaric oxygenation during the incubational period led to a certain aggravation of infection as evidenced by a greater accumulation of the agent in the central nervous system (CNS) and spleen, as well as by more pronounced ultramicroscopic changes in CNS. A single exposure to hypoxia failed to alter any manifestations of infection.
MH Animal; Anoxia; Brain/pathology; *Hyperbaric Oxygenation; Mice; Mice, Inbred BALB C; Scrapie/pathology/*physiopathology/therapy; Sheep; Spleen/pathology
SP englisch
PO Tschechoslowakei