NR AKET
AU Roth,A.M.; Keltner,J.L.; Ellis,W.G.; Martins-Green,M.
TI Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease
QU American Journal of Ophthalmology 1979 Jun; 87(6): 827-33
PT journal article
AB A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.
MH Aged; Brain/pathology; Brain Chemistry; Case Report; Creutzfeldt-Jakob Syndrome/*pathology; Human; Male; Optic Nerve/*pathology/ultrastructure; Virion/*analysis
SP englisch
PO USA