NR AKGO
AU Rutala,W.A.; Weber,D.J.
TI Creutzfeldt-Jakob disease: recommendations for disinfection and sterilization.
QU Clinical Infectious Diseases 2001 May 1; 32(9): 1348-56
PT journal article
AB Prion diseases constitute a unique infection control problem because prions exhibit unusual resistance to conventional chemical and physical decontamination methods. Recommendations to prevent cross-transmission of infection from medical devices contaminated by Creutzfeldt-Jakob disease (CJD) have been based primarily on prion inactivation studies. The recommendations in this article consider inactivation data but also use epidemiological studies of prion transmission, infectivity of human tissues, and efficacy of removing microbes by cleaning. On the basis of the scientific data, only critical (e.g., surgical instruments) and semicritical devices contaminated with high-risk tissue (i.e., brain, spinal cord, and eye tissue) from high-risk patients - those with known or suspected infection with CJD - require special treatment.
MH Animal; Creutzfeldt-Jakob Syndrome/epidemiology/etiology/*prevention & control; Disinfection/methods/*standards; Human; *Practice Guidelines; Sterilization/methods/*standards
AD Division of Infectious Diseases, University of North Carolina (UNC) School of Medicine and the Department of Hospital Epidemiology, UNC Health Care System, Chapel Hill, NC 27599-7030, USA
SP englisch
PO USA