NR AKIF
AU Saiz,A.; Graus,F.; Dalmau,J.; Pifarre,A.; Marin,C.; Tolosa,E.
TI Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders
QU Annals of Neurology 1999 Nov; 46(5): 774-7
KI Ann Neurol. 2000 May;47(5):683-4. PMID: 10805347
PT journal article
AB The detection of 14-3-3 protein in cerebrospinal fluid by immunoblotting is useful for the diagnosis of Creutzfeldt-Jakob disease (CJD). We found 14-3-3 protein in 10 of 80 (12.5%) patients with paraneoplastic neurological disorders (PNDs), whose presenting symptoms may mimic those of CJD. In 47 of 48 CJD patients, the 14-3-3 protein was detected as a single band, and it was detected as a double band in 1 patient. The double-band pattern was observed in 9 of 10 14-3-3 protein-positive patients with PNDs. The 14-3-3 protein assay may be positive in PND patients, but the immunoblotting pattern distinguishes most PND samples from those of CJD.
MH Aged; Brain/*metabolism; Creutzfeldt-Jakob Syndrome/cerebrospinal fluid/diagnosis; Diagnosis, Differential; Female; Human; Immunoblotting; Limbic Encephalitis/*cerebrospinal fluid; Male; Middle Age; Paraneoplastic Cerebellar Degeneration/*cerebrospinal fluid; Paraneoplastic Syndromes, Nervous System/*cerebrospinal fluid/diagnosis; Predictive Value of Tests; Proteins/*analysis; Support, Non-U.S. Gov't
AD Service of Neurology and Institute d'Investigacio Biomedica August Pi i Sunyer, Barcelona, Spain.
SP englisch
PO USA