NR AKIZ
AU Salvatore,M.; Seeber,A.C.; Nacmias,B.; Petraroli,R.; D'Alessandro,M.; Sorbi,S.; Pocchiari,M.
TI Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease
QU Neuroscience Letters 1995 Oct 20; 199(2): 95-8
PT clinical trial; journal article
AB We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and ten familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, ApoE genotypes and allelic frequencies do not significantly differ from that of controls. No influence of ApoE genotypes on age at onset was found. In familial cases, the disease appeared in mutated subjects showing the same ApoE genotype as members who have not yet developed CJD. Our results provide further evidence that ApoE is not a risk factor for CJD.
IN Bei 49 sogenannten sporadischen Fällen von Creutzfeldt-Jakob-Krankheit wurden keine signifikannt anderen Häufigkeiten verschiedener Apolipoproteinallele und keine anderen Erkrankungsalter als in 84 Kontrollen gefunden. Bei 10 erblichen Fällen konnte kein Unterschied zu nicht betroffenen Familienmitgliedern gefunden werden. Dies spricht gegen einen Einfluß der Form des Apolipoproteins.
ZR 18
MH Aged; Aged, 80 and over; Alleles; Apolipoproteins E/genetics/*metabolism; Creutzfeldt-Jakob Syndrome/genetics/*metabolism; Female; Genetic Markers; Genotype; Human; Italy; Male; Risk Factors; Support, Non-U.S. Gov't
AD Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy.
SP englisch
PO Irland