NR AKJY
AU Sapriel,G.
TI Prion model in yeast
QU Research in Microbiology 2001 Jul-Aug; 152(6): 531-8
PT journal article; review; review, tutorial
AB Two unusual phenotypes in Saccharomyces cerevisiae, [PSI+] and [URE3], have been suggested to be due to prion proteins. Various research groups have shown that this is indeed the case and have characterized these yeast prions in more detail. The factors involved in prion formation, such as chaperone protein, and the intramolecular determinants of prion formation have been investigated. The ability of these yeast proteins to form prion is due to modular domains conserved throughout evolution.
ZR 43
MH Amino Acid Sequence; Conserved Sequence; Fungal Proteins/biosynthesis/chemistry/genetics; Molecular Sequence Data; Prions/*biosynthesis/chemistry/genetics; Protein Conformation; Yeasts/chemistry/genetics/*metabolism
AD Departement des biotechnologies, Institut Pasteur, Paris, France. gsapriel@pasteur.fr
SP englisch
PO Frankreich