NR AKLG
AU Saunders,A.M.; Schmader,K.; Breitner,J.C.S.; Benson,M.D.; Brown,W.T.; Goldfarb,L.; Goldgaber,D.; Manwaring,M.G.; Szymanski,M.H.; McCown,N.; Dote,K.C.; Schmechel,D.E.; Strittmatter,W.J.; Pericak-Vance,M.A.; Roses,A.D.
TI Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
QU Lancet 1993 Sep 18; 342(8873): 710-1
KI Lancet. 1993 Sep 18;342(8873):696
PT journal article
AB The frequency of the allele for apolipoprotein E type 4 (epsilon 4) is increased in late-onset familial and sporadic Alzheimer's disease (AD). We have examined epsilon 4 frequencies in four distinct, normal, elderly control groups and, most importantly, in patients with amyloid-forming diseases whose epsilon 4 distributions were not previously known (Creutzfeldt-Jakob disease, familial amyloidotic polyneuropathy, Down's syndrome). There were no differences between any of these controls and published control series, cementing the relevance of epsilon 4 for late-onset AD. The increase in late-onset AD was confirmed in two new series.
MH Age Factors; Aged; *Alleles; Alzheimer Disease/*genetics; Amyloidosis/genetics; Apolipoproteins E/*genetics; Creutzfeldt-Jakob Syndrome/genetics; Down Syndrome/genetics; Gene Frequency; Hereditary Sensory and Autonomic Neuropathies/genetics; Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Bryan Alzheimer's Disease Research Center, Division of Neurology, Duke University Medical Center, Durham, NC 27710.
SP englisch
PO England