NR AKNG
AU Schluesener,H.J.; Meyermann,R.
TI Intercrines in brain pathology. Expression of intercrines in a multiple sclerosis and Morbus Creutzfeldt-Jakob lesion.
QU Acta Neuropathologica 1993; 86(4): 393-6
PT journal article
AB Expression of cytokine genes regulating vascular permeability and chemoattraction was studies by polymerase chain reaction in RNA from two different types of brain lesions: a multiple sclerosis plaque and in tissue from a patient with Creutzfeldt-Jakob disease. While cytokine genes encoding vascular permeability factor, interleukin (IL)-2, IL-4, or IL-10, generally associated with active inflammatory processes, were not expressed, we observed expression of some intercrine genes in both types of lesions. As these lesions share a common set of structural features such as prominent astrogliosis and glial cells are known producers of intercrines, we suggest that intercrines have a role in the formation of gliotic brain lesions.
MH Aged; Brain/metabolism/*pathology; Creutzfeldt-Jakob Syndrome/genetics/*pathology; Cytokines/*biosynthesis/genetics; Electrophoresis, Agar Gel; Female; Gene Expression Regulation; Human; Interleukins/biosynthesis/genetics; Male; Multiple Sclerosis/genetics/*pathology; Polymerase Chain Reaction; RNA/isolation & purification; Support, Non-U.S. Gov't
AD Institut für Hirnforschung, Eberhard-Karls Universität Tübingen, Germany.
SP englisch
PO Deutschland