NR AKOT
AU Schröder,R.; Linke,R.P.
TI Cerebrovascular involvement in systemic AA and AL amyloidosis: a clear haematogenic pattern.
QU Virchows Archiv 1999 Jun; 434(6): 551-60
IA http://springerlink.metapress.com/content/q50wnqkjt3ppqpdl/fulltext.pdf
PT journal article
AB Amyloid deposits in cerebral vessels are common in beta-amyloid diseases (Alzheimer's disease, congophilic amyloid angiopathy, Down's syndrome and hereditary cerebral amyloidosis with haemorrhage of the Dutch type). We report of 20 autopsies on patients who had died with systemic amyloidosis of the AA, Alambda and Akappa types: the brains were examined for the occurrence of amyloid. Vascular amyloid was detected in choroid plexus (in 17 of 20 cases), infundibulum (5 of 8), area postrema (6 of 11), pineal body (3 of 7) and subfornical organ (2 of 3), but not in cortical and leptomeningeal vessels. Immunohistochemical classification of the cerebral amyloid and the systemic amyloid syndrome showed identity proving the same origin of both. The distribution is indicative of a haematogenic pattern of amyloid deposition in systemic amyloidosis and is different from that in Alzheimer's, prion, ATTR and cystatin C diseases. It corresponds to areas of the brain with a "leaky" blood-brain barrier. Additionally, all the cases with AA amyloidosis exhibited an Abeta coreactivity in choroid plexus vessels. In one exceptional case, Abeta reactivity of AA amyloid also occurred outside of the brain.
MH Adult; Aged; Amyloid Protein AA/*analysis; Amyloidosis/*metabolism/pathology; Blood-Brain Barrier; Brain Diseases/*metabolism/pathology; Choroid Plexus/chemistry; Female; Human; Immunoglobulins, Light-Chain/*analysis; Immunohistochemistry; Male; Middle Age; Support, Non-U.S. Gov't
AD Institut für Pathologie, Neuropathologie, Universität Köln, Cologne, Germany.
SP englisch
PO Deutschland