NR AKQA
AU Scott,J.R.; Fraser,H.
TI Enucleation after intraocular scrapie injection delays the spread of infection
QU Brain Research 1989 Dec 18; 504(2): 301-5
PT journal article
AB After right intraocular infection, mice develop lesions in the contralateral retinal projections long before clinical disease occurs. Enucleation up to 7 days post-infection prevented targeting of lesions to visual projections, and prolonged the incubation period. When enucleation was delayed until at least 14 days post-infection, lesion targeting and incubation periods were similar to unenucleated mice. It was concluded that infectivity took a minimum of 14 days to reach the brain via the optic nerve.
MH Animal; Eye/*microbiology; Injections; Mice; Ophthalmologic Surgical Procedures; Prions/*pathogenicity; Scrapie/pathology/physiopathology/*surgery; Superior Colliculus/*microbiology/pathology; Time Factors
AD AFRC and MRC Neuropathogenesis Unit, Institute for Animal Health, Edinburgh, U.K.
SP englisch
PO Niederlande