NR AKSE
AU Serio,T.R.; Lindquist,S.L.
TI Protein-only inheritance in yeast: something to get [PSI+]-ched about.
QU Trends in Cell Biology 2000 Mar; 10(3): 98-105
PT journal article; review; review, tutorial
AB Recent work suggests that two unrelated phenotypes, [PSI+] and [URE3], in the yeast Saccharomyces cerevisiae are transmitted by non-covalent changes in the physical states of their protein determinants, Sup35p and Ure2p, rather than by changes in the genes that encode these proteins. The mechanism by which alternative protein states are self-propagating is the key to understanding how proteins function as elements of epigenetic inheritance. Here, we focus on recent molecular-genetic analysis of the inheritance of the [PSI+] factor of S. cerevisiae. Insights into this process might be extendable to a group of mammalian diseases (the amyloidoses), which are also believed to be a manifestation of self-perpetuating changes in protein conformation.
ZR 60
MH Extrachromosomal Inheritance/*genetics; Fungal Proteins/genetics/*metabolism; Heat-Shock Proteins/metabolism; Heat-Shock Proteins 70/metabolism; Phenotype; Prions/genetics/metabolism; Protein Binding/genetics; Repressor Proteins/*metabolism; Saccharomyces cerevisiae/*genetics/*metabolism; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Translation, Genetic
AD Dept of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
SP englisch
PO England