NR AKST
AU Shaked,G.M.; Engelstein,R.; Avraham,I.; Rosenmann,H.; Gabizon,R.
TI Valproic acid treatment results in increased accumulation of prion proteins
QU Annals of Neurology 2002 Oct; 52(4): 416-20
PT journal article
AB PrPsc, the only identified component of the prion, is an aberrant isoform of PrPc, a glycoprotein of unknown function. In this study, it was shown that valproic acid, a widely used antiepileptic drug, can cause an increase of several orders of magnitude in the accumulation of PrPc in normal neuroblastoma cells (N2a), and of both PrP isoforms in scrapie infected neuroblastoma cells (ScN2a). Although preliminary results indicate that valproic acid administration to hamsters inoculated with prions had no significant effect on disease incubation time, it is suggested that administration of valproic acid to humans at risk of developing Creutzfeldt-Jakob disease should be evaluated with caution.
MH Animal; Anticonvulsants/contraindications/*pharmacology; Culture Media/pharmacology; Dose-Response Relationship, Drug; Hamsters; *Neuroblastoma; PrPc Proteins/metabolism; PrPsc Proteins/metabolism; Prions/*metabolism; Scrapie/*metabolism; Tumor Cells, Cultured/drug effects/metabolism; Valproic Acid/contraindications/*pharmacology
AD Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel.
SP englisch
PO USA