NR AKWS
AU Simmons,M.M.; Harris,P.; Jeffrey,M.J.; Meek,S.C.; Blamire,I.W.H.; Wells,G.A.H.
TI BSE in Great Britain: consistency of the neurohistopathological findings in two random annual samples of clinically suspect cases.
QU The Veterinary Record 1996 Feb 24; 138(8): 175-7
PT journal article
AB Two annual, random samples of clinically suspect cases of bovine spongiform encephalopathy (BSE) were taken in 1992-93 (year 1, 1500 cases) and 1993-94 (year 2, 1000 cases). From each sample, 100 positive cases were examined in detail to establish the severity of the vacuolation in 17 specific neuroanatomical locations. The resultant 'lesion profiles' were compared with the profile obtained from a similar sample of BSE-affected cattle from early in the epidemic (1987-89); the comparison showed that the distribution and severity of vacuolation in BSE has remained unchanged. The cases not confirmed as BSE on histological examination (172 in year 1 and 162 in year 2) were examined for evidence of any alternative neurohistological diagnosis. As in previous studies, the majority of these cases showed no significant lesions (61.6 and 61.7 per cent). The remainder consisted of bilateral focal spongiosis of unknown significance (26.7 and 21.0 per cent), inflammatory conditions (8.1 and 11.1 per cent) and a small number of cases with tumours, cerebrocortical necrosis or idiopathic brainstem neuronal chromatolysis. No evidence was found of any cases of BSE with an atypical distribution of lesions. These findings support the theory that the BSE epidemic is sustained by a single, stable strain of the BSE agent, and confirm that the existing statutory diagnostic criteria continue to be appropriate.
IN Bei je 100 Gehirnen von in den Untersuchungsjahren 1992-93 und 1993-94 als BSE-positiv diagnostizierten Rindern wurde das Ausmaß der Vakuolisierung an 17 definierten Punkten analysiert. Die Verteilung und die Schwere der Schädigungen unterschieden sich nicht von den im Untersuchungsjahr 1987-88 gefundenen Schädigungsmustern. Die Autoren gehen deshalb davon aus, dass es in England nur einen BSE-Erregerstamm gebe.
ZR 21
MH Animal; Brain/*pathology/ultrastructure; Brain Stem/pathology; Cattle; Comparative Study; Encephalopathy, Bovine Spongiform/*epidemiology/*pathology; Great Britain/epidemiology; Necrosis; Phenotype; Retrospective Studies; Support, Non-U.S. Gov't; Vacuoles/ultrastructure
AD M.M.Simmons, P.Harris, S.C.Meek, I.W.H.Blamire, G.A.H.Wells, Central Veterinary Laboratory, New Haw, Addlestone, Surrey KT15 3NB; M.Jeffrey, Lasswade Veterinary Laboratory, Bush Estate, Penicuik, Midlothian EH26 OSA
SP englisch
PO England