NR ALAW
AU Sorbi,S.; Antuono,P.; Amaducci,L.
TI Choline acetyltransferase and acetylcholinesterase abnormalities in senile dementia: importance of biochemical measurements in human post-mortem brain specimens.
QU Italian Journal of Neurological Sciences 1980 Mar; 1(2): 75-83
PT journal article
AB Choline acetyltransferase and acetylcholinesterase have been assessed in human aging brains, in demented and agonal states. Choline acetyl transferase decreased during aging in normal brain when measured in the cerebral cortex. Choline acetyltransferase was also reduced in several other brain areas in patients with Alzheimer's disease and in one patient with Creutzfeldt-Jakob disease. Choline acetyltransferase was also reduced in bronchopneumonia and in some terminal conditions. On the contrary, the activity was not reduced in patients who died after cerebrovascular accidents. Acetylcholine esterase, although it followed the general trend of choline acetyltransferase, did not yield significant results.
IN In der Hirnrinde eines CJD-Patienten wurde eine reduzierte Aktivität der Cholinacetyltransferase festgestellt.
MH Acetylcholinesterase/*metabolism; Aged; Alzheimer Disease/*enzymology; Brain/*enzymology; Bronchopneumonia/enzymology; Cerebrovascular Disorders/enzymology; Choline O-Acetyltransferase/*metabolism; Coma/enzymology; Comparative Study; Creutzfeldt-Jakob Syndrome/*enzymology; Dementia/*enzymology; Human; Middle Age; Postmortem Changes; Support, Non-U.S. Gov't
SP englisch
PO Italien