NR ALBH
AU Soto,C.
TI Alzheimer's and prion disease as disorders of protein conformation: implications for the design of novel therapeutic approaches.
QU Journal of Molecular Medicine 1999 May; 77(5): 412-8
PT journal article; review; review, tutorial
AB Several lines of evidence suggest that a defective protein folding is a central event in both Alzheimer's and prion disease. Although the two disorders are very different clinically, neuropathologically, and biochemically, the molecular event that may trigger the disease process appears to be the same: the formation of an altered protein conformer composed of a high content of beta-sheet structure. Compounds with the ability to prevent and to reverse protein conformational changes may be useful as novel therapeutic approaches for Alzheimer's disease, prion disease, and other disorders of defective protein folding.
ZR 74
MH Alzheimer Disease/*drug therapy/metabolism; Amyloid beta-Protein/*chemistry/genetics; Brain Chemistry; Human; Mutation; Peptides/*therapeutic use; Prion Diseases/*drug therapy/metabolism; Prions/*chemistry/genetics; Protein Conformation; Protein Structure, Secondary; Support, U.S. Gov't, P.H.S.
AD Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago. sotojc01@popmail.med.nyu.edu
SP englisch
PO Deutschland