NR ALDI
AU Steelman,V.M.
TI Creutzfeldt-Jakob disease: recommendations for infection control.
QU American Journal of Infection Control 1994 Oct; 22(5): 312-8
PT journal article
AB Creutzfeldt-Jakob disease, an infectious, progressive, degenerative neurologic disorder, has a presumably long incubation period but a rapid, fatal course. Brain tissue at autopsy resembles that seen in spongioform encephalopathies of other species. Creutzfeldt-Jakob disease is transmitted by a proteinaceous infectious agent, or "prion." Epidemiologic patterns remain uncertain; various studies have reported conflicting risk factors in different populations, and genetic susceptibility may be involved. Although natural transmission routes are still unclear, both iatrogenic and nosocomial transmissions have been identified. Transmission has occurred through contaminated electrodes, contaminated biologic products from cadaveric brains, and infected donor tissues, including dura mater and corneas. Because the prion is difficult to eradicate, stringent sterilization precautions must be taken with all surgical instruments. Some tissues and body fluids (e.g., brain, ocular, central nervous system) from the patient with Creutzfeldt-Jakob disease are highly infectious and must be contained or incinerated. Some body fluids, however, are not considered infectious. Persons with known or suspected Creutzfeldt-Jakob disease, or with exposure to potential sources of iatrogenic infection, should not be considered as donors for any tissues or biologic products. Occupational transmission to health care and pathology workers is also possible. Therefore, specific preventive measures are necessary. Many questions remain regarding transmission and risk factors for Creutzfeldt-Jakob syndrome, and the precautions presented here must be considered only preliminary.
MH Comparative Study; Creutzfeldt-Jakob Syndrome/epidemiology/*prevention & control/transmission; Cross Infection/prevention & control/transmission; Disease Transmission, Patient-to-Professional/prevention & control; Disinfection; Female; Human; Infection Control/*standards; Male; Occupational Exposure/prevention & control; Operating Rooms/standards; Pathology Department, Hospital/standards; Personnel, Hospital; Sterilization; United States
AD University of Iowa Hospitals and Clinics, Iowa City 52242-1009.
SP englisch
PO USA