NR ALDP
AU Steinhoff,B.J.; Racker,S.; Herrendorf,G.; Poser,S.; Grosche,S.; Zerr,I.; Kretzschmar,H.A.; Weber,T.
TI Accuracy and reliability of periodic sharp wave complexes in Creutzfeldt-Jakob disease
QU Archives of Neurology 1996 Feb; 53(2): 162-6
PT clinical trial; journal article
AB OBJECTIVE: To assess the sensitivity, specificity, and interobserver reliability of periodic sharp wave complexes in the electroencephalograms of patients with Creutzfeldt-Jakob disease. DESIGN: Sixty-eight electroencephalograms in 29 patients who had been suspected of having Creutzfeldt-Jakob disease were reanalyzed by an investigator who was unaware of the clinical data. The incidence of periodic sharp wave complexes in neuropathologically confirmed Creutzfeldt-Jakob disease vs progressive dementia other than Creutzfeldt-Jakob disease was assessed. Blinded electroencephalogram analysis was performed by a second investigator. The interobserver reliability was assessed by the kappa value. SETTING: University hospital, base of the German National Creutzfeldt-Jakob Disease Surveillance Study. PATIENTS: Fifteen patients with neuropathologically confirmed Creutzfeldt-Jakob disease and 14 patients who had been suspected of having Creutzfeldt-Jakob disease because of rapidly progressive dementia but in whom other dementias were diagnosed by unblinded investigators based on clinical and electroencephalographic criteria. MAIN OUTCOME MEASURE: Sensitivity and specificity of periodic sharp wave complexes assessed by their incidence in Creutzfeldt-Jakob disease vs other dementias. Interobserver reliability of periodic sharp wave complexes was expressed by the kappa value. RESULTS: For periodic sharp wave complexes, blinded electroencephalographic analysis resulted in a sensitivity and a specificity of 67% and 86%, respectively. Interobserver reliability was excellent (kappa = 0.95). CONCLUSION: This blinded electroencephalographic study in Creutzfeldt-Jakob disease confirms the high diagnostic value of electroencephalography, as previously reported by open studies.
ZR 54
MH Aged; Aged, 80 and over; Brain/physiopathology; Creutzfeldt-Jakob Syndrome/*diagnosis/physiopathology; *Electroencephalography; Female; Human; Male; Middle Age; Observer Variation; Periodicity; Predictive Value of Tests; Reproducibility of Results; Sensitivity and Specificity; Support, Non-U.S. Gov't
AD Department of Clinical Neurophysiology, Georg-August University, Göttingen, Germany.
SP englisch
PO USA