NR ALDV
AU Stephenson,D.A.; Chiotti,K.; Ebeling,C.; Groth,D.; DeArmond,S.J.; Prusiner,S.B.; Carlson,G.A.
TI Quantitative trait loci affecting prion incubation time in mice
QU Genomics 2000 Oct 1; 69(1): 47-53
PT journal article
AB Although the gene encoding prion protein (PrP) is the major determinant of susceptibility to prion disease, other genes also affect prion incubation time in mice and may be involved in prion replication. Scrapie incubation time was analyzed as a quantitative trait using crosses between SJL/J and CAST/Ei mice; these mouse strains encode identical PrP molecules but have different incubation periods. Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility.
IN Stephenson et al. kreuzten die beiden Mausstämme SJL/J und CAST/Ei, die beide exakt das selbe Prionprotein exprimierten und dennoch bei Scrapie-Infektionen unterschiedliche Inkubationszeiten zeigten. Sie konnten Bereiche auf den Chromosomen 9 und 11 mit der Scrapie-Infektionszeit in Verbindung bringen.
MH Animal; Chromosome Mapping; Crosses, Genetic; Female; Genome; Linkage (Genetics); Lod Score; Male; Mice; Mice, Inbred Strains; Microsatellite Repeats; PrPsc Proteins/*genetics; Prion Diseases/*genetics; *Quantitative Trait, Heritable; Scrapie/genetics; Species Specificity; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Time Factors
AD Dennis A. Stephenson, Kami Chiotti, Christine Ebeling, George A. Carlson (gac@po.mri.montana.edu), McLaughlin Research Institute, Great Falls, Montana 59405, USA; Dennis A. Stephenson, Associate of the Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA; Darlene Groth, Stephen J. DeArmond, Stanley B. Prusiner, Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94143, USA; Darlene Groth, Stanley B. Prusiner, Department of Neurology, University of California, San Francisco, California 94143, USA; Stephen J. DeArmond, Department of Pathology, University of California, San Francisco, California 94143, USA
SP englisch
PO USA