NR ALFX
AU Suenaga,T.; Hirano,A.; Llena,J.F.; Ksiezak-Reding,H.; Yen,S.H.; Dickson,D.W.
TI Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease
QU Annals of Neurology 1990 Aug; 28(2): 174-7
PT journal article
AB Cerebellar kuru plaques in 2 cases of Creutzfeldt-Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin-positive, tau-negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt-Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.
MH Aged; Cerebellum/*chemistry/ultrastructure; Creutzfeldt-Jakob Syndrome/*metabolism/pathology; Human; Middle Age; Support, U.S. Gov't, P.H.S.; Ubiquitins/*analysis
AD Department of Pathology, Montefiore Medical Center, Bronx, NY 10467.
SP englisch
PO USA