NR ALGH
AU Sulkowski,E.
TI Spontaneous conversion of PrPc to PrPsc
QU FEBS Letters 1992 Jul 28; 307(2): 129-30
PT journal article; review; review, tutorial
AB Octa-repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrPc (cellular) isoform into PrPsc (scrapie) isoform may be triggered by the coordination of these metals.
ZR 18
MH Animal; Human; Membrane Glycoproteins/chemistry/*metabolism; Metals/*metabolism; PrPsc Proteins; Prions/chemistry/*metabolism; Protein Conformation
AD Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263.
SP englisch
PO Niederlande