NR ALGZ
AU Sutherland,K.; Ironside,J.W.
TI Novel application of image analysis to the detection of spongiform change
QU Analytical and Quantitative Cytology and Histology 1994 Dec; 16(6): 430-4
PT journal article
AB Spongiform change is the characteristic neuropathologic abnormality within the brain in Creutzfeldt-Jakob disease, the most common human spongiform encephalopathy, but traditional methods of evaluating this abnormality are subjective and laborious. In order to overcome these difficulties, a quantitative method of assessment of spongiform change was devised and implemented using image analysis techniques. Successful validation of this system was performed by subjective and objective comparison with a neuropathologist's assessment. In a test-set of 50 microscopic images a strong positive rank correlation (Rs = 0.91) was established between the image analyzer and the neuropathologist. This system should facilitate large-scale analysis of different patterns of spongiform change in cases of human spongiform encephalopathy.
MH Brain/*pathology; Human; Image Processing, Computer-Assisted; Prion Diseases/*pathology; Support, Non-U.S. Gov't
AD CJD Surveillance Unit, Western General Hospital, Edinburgh, U.K.
SP englisch
PO USA