NR ALJS
AU Tamai,Y.; Ohtani,Y.; Miura,S.; Narita,Y.; Iwata,T.; Kaiya,H.; Namba,M.
TI Creutzfeldt-Jakob disease - alteration in ganglioside sphingosine in the brain of a patient
QU Neuroscience Letters 1979 Jan; 11(1): 81-6
PT journal article
AB Gangliosides isolated from the brain of patients with Creutzfelt-Jakob (C-J) disease were analyzed. The ganglioside current was abnormally low, and the percentage distributions of individual gangliosides and the long-chain base compositions were abnormal. The C20-sphingosine contents of all the ganglioside fractions were low. Abnormalities in ganglioside long-chain bases in adult human brain have been reported previously only in patients with inherited metabolic disorders. These abnormalities in C-J disease seem to be closely related to the cause of the disease.
MH *Brain Chemistry; Chemistry; Creutzfeldt-Jakob Syndrome/*metabolism; Female; Gangliosides/*analysis; Human; Middle Age; Sphingosine/analysis
SP englisch
PO Niederlande