NR ALLL
AU Tateishi,J.; Tashima,T.; Kitamoto,T.
TI Practical methods for chemical inactivation of Creutzfeldt-Jakob disease pathogen
QU Microbiology and Immunology 1991; 35(2): 163-6
PT journal article
AB Chemical inactivation of pathogen of Creutzfeldt-Jakob disease (CJD) was examined using the mouse-adapted CJD strain. A high concentration of formic acid, guanidine compounds, trichloroacetate and phenol prevented CJD transmission. NaOH between 0.25 and 2 N lengthened the incubation periods. Sodium dodecyl sulfate (SDS) in a concentration between 1 and 3% did not alter incubation at room temperature but did completely block the transmission after boiling for 3 min in 3% SDS. This method is recommended for practical disinfection.
MH Acids; Alcohols; Alkalies; Animal; Brain/microbiology; Creutzfeldt-Jakob Syndrome/*microbiology; Disease Models, Animal; Disinfection; Female; Mice; *Prions; Support, Non-U.S. Gov't; Virulence; *Virus Activation
AD Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka.
SP englisch
PO Japan
OR Prion-Krankheiten 8