NR ALLV

AU Tateishi,J.; Tsuji,S.

TI Unconventional pathogens causing spongiform encephalopathies absent in blood products

QU Journal of Medical Virology 1985 May; 16(1): 11-5

PT journal article

AB To determine whether unconventional pathogens causing subacute spongiform encephalopathy may be present in blood products, a newly developed hepatitis B vaccine and a widely used blood product were injected into mice and rats. As only a few aged mice in the test and the control groups showed spongiform encephalopathic change of a sparse or mild degree and which differed from that seen in rodents infected with Creutzfeldt-Jakob disease, the presence of unconventional pathogens in the tested inocula can be ruled out.

IN Die Autoren injizierten vermutlich intrazerebral Mäusen und Ratten eine Hepatitis-B-Vaccine und ein viel benutztes Blutprodukt und fanden nur bei einigen alten Tieren in der Test- und in der Kontrollgruppe leichte, ihrer Erfahrung nach nicht CJD-typische spongiforme Veränderungen. Sehr naiv, folgern die Autoren daraus, diese Produkte seien sicher.

MH Animal; *Blood Proteins; Brain/pathology; Brain Diseases/*microbiology/pathology; Creutzfeldt-Jakob Syndrome/etiology; *Drug Contamination; Female; Hepatitis B/*blood; Hepatitis B Vaccines; Liver/pathology; Mice; Rats; Rats, Inbred Strains; Slow Virus Diseases/*microbiology; *Viral Hepatitis Vaccines

SP englisch

PO USA

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