NR ALMU
AU Taylor,D.M.
TI Inactivation of transmissible degenerative encephalopathy agents: A review.
QU Veterinary Journal 2000 Jan; 159(1): 10-7
IA http://www.cwd.cc/Inactivation%20of%20Transmissible%20Degenerative%20Encephalopathy%20Agents%20-%20A%20Review.pdf
KI Vet J. 2000 Jan;159(1):3-4. PMID: 10640405
PT journal article; review; review, tutorial
AB The unconventional agents that cause transmissible degenerative encephalopathies, such as bovine spongiform encephalopathy, scrapie, and Creutzfeldt-Jakob disease (CJD), are relatively resistant to inactivation by standard decontamination procedures. The only methods that appear to be completely effective under worst-case conditions are strong sodium hypochlorite solutions or hot solutions of sodium hydroxide. Other procedures that result in significant degrees of inactivation are described. The infectivity levels in histologically-fixed tissue can be reduced substantially by treatment with concentrated formic acid without adversely affecting the microscopic quality of the tissue.
ZR 66
MH Animal; Decontamination; Guinea Pigs; Hamsters; Human; Mice; Prion Diseases/*prevention & control/*transmission/veterinary; Prions/*antagonists & inhibitors; Sodium Hydroxide; Sodium Hypochlorite; Support, Non-U.S. Gov't
AD Neuropathogenesis Unit, Institute for Animal Health, West Mains Road, Edinburgh, EH9 3JF, UK. david-taylor@bbsrc.ac.uk
SP englisch
PO England