NR ALPQ
AU Ter-Avanesyan,M.D.; Shitikova,I.E.; Zavalishin,I.A.; Smirnov,V.N.
TI [Prion phenomenon in medicine and biology]
OT Fenomen prionov v meditsine i biologii
QU Rossiiskii Fiziologicheskii Zhurnal Imenti I.M. Sechenova / Rossiiskaia Akademiia Nauk 1999 Jul; 85(7): 984-96
PT journal article; review; review, tutorial
AB The data obtained suggest that the fatal changes in brain tissue associated with the prion diseases, are initiated by a conformational rearrangement of constitutively expressed cellular protein PrP. Possible mechanisms of such a conversion of this protein are discussed. Existence of the proteins with the prion properties in low eukaryotes may determine the unusual mechanisms of the "protein" inheritance. A new experimental model for studying the proteins with the prion properties in the yeast Saccharomyces cerevisiae, is described.
ZR 47
MH Animal; English Abstract; Fungal Proteins/genetics; Human; Prion Diseases/*genetics; Prions/chemistry/*genetics/pathogenicity; Protein Conformation
AD Cardiological Research-Industrial Complex, Moscow, Russia.
SP russisch
PO Russland