NR ALRQ
AU Tiwana,H.; Wilson,C.; Pirt,J.; Cartmell,W.; Ebringer,A.
TI Autoantibodies to brain components and antibodies to Acinetobacter calcoaceticus are present in bovine spongiform encephalopathy
QU Infection and Immunity 1999 Dec; 67(12): 6591-5
IA http://iai.asm.org/cgi/reprint/67/12/6591.pdf
PT journal article
AB Bovine spongiform encephalopathy (BSE) is a neurological disorder, predominantly of British cattle, which belongs to the group of transmissible spongiform encephalopathies together with Creutzfeldt-Jakob disease (CJD), kuru, and scrapie. Autoantibodies to brain neurofilaments have been previously described in patients with CJD and kuru and in sheep affected by scrapie. Spongiform-like changes have also been observed in chronic experimental allergic encephalomyelitis, at least in rabbits and guinea pigs, and in these conditions autoantibodies to myelin occur. We report here that animals with BSE have elevated levels of immunoglobulin A autoantibodies to brain components, i.e., neurofilaments (P < 0.001) and myelin (P < 0.001), as well as to Acinetobacter calcoaceticus (P < 0.001), saprophytic microbes found in soil which have sequences cross-reacting with bovine neurofilaments and myelin, but there were no antibody elevations against Agrobacterium tumefaciens or Escherichia coli. The relevance of such mucosal autoantibodies or antibacterial antibodies to the pathology of BSE and its possible link to prions requires further evaluation.
MH Acinetobacter calcoaceticus/chemistry/*immunology; Amino Acid Sequence; Animal; Antibodies, Bacterial/*blood; Autoantibodies/*blood; Bacterial Proteins/chemistry; Brain/*immunology; Cattle; Encephalopathy, Bovine Spongiform/complications/*immunology; Myelin Sheath/immunology; Neurofilament Proteins/chemistry/immunology; Rabbits; Support, Non-U.S. Gov't
AD Infection and Immunity Group, Division of Life Sciences, King's College, London, United Kingdom.
SP englisch
PO USA