NR ALTL
AU Trento,F.; Cattaneo,F.; Pescador,R.; Porta,R.; Ferro,L.
TI Antithrombin activity of an algal polysaccharide
QU Thrombosis Research 2001 Jun 1; 102(5): 457-65
PT journal article
AB In an effort to reduce the risks of a possible iatrogenic transmission of bovine spongiform encephalitis (BSE) through the use of bovine-derived medicinal products, we patented in the USA in 1999 a polysaccharide from brown algae, endowed with interesting pharmacological activities: (a) concentration-dependent inhibition of thromboplastin or cephalin-kaolin-induced thrombin generation from platelets, (b) concentration-dependent inhibition of thrombin-induced platelet aggregation, (c) thrombin has hypotensive effect, which was blunted and zeroed by our fucansulfate in a dose-dependent way, (d) when aortae are stimulated with thrombin, they become stickier for polymorphonucleated leukocytes (PMNs); our fucansulfate decreased concentration-dependently, PMNs sticking to autologous rabbit aortae, (e) dose-dependent inhibition of thrombin-induced thrombosis. All the above data suggest that our fucansulfate could be a heparin substitute endowed with antithrombotic and anti-inflammatory activities, devoid or the problems caused to heparin by its animal origin, i.e., possible prion protein contamination.
MH Algae, Brown/*chemistry; Animal; Antithrombins/pharmacology; Aorta/metabolism; Cell Adhesion/drug effects; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents/*pharmacology; Heparin/pharmacology; Hirudin/pharmacology; Male; Neutrophils/drug effects/metabolism; Platelet Aggregation/drug effects; Polysaccharides/*pharmacology; Rabbits; Thrombin/administration & dosage/*antagonists & inhibitors/pharmacology; Thrombosis/chemically induced/drug therapy/prevention & control
AD Pharma Research Laboratories, Piazza XX Settembre 2, 22079 Villa Guardia, Como, Italy.
SP englisch
PO USA