NR ALXY
AU van Everbroeck,B.R.J.; Pals,P.; Martin,J.J.; Cras,P.
TI Transmissible spongiform encephalopathies: the story of a pathogenic protein.
QU Peptides 2002 Jul; 23(7): 1351-9
PT journal article
AB An overview is provided from the first description of the transmissible spongiform encephalopathies (TSE) to recent major discoveries in this research field. The TSE are a group of diseases in animal and in man caused by a unique pathogen: the prion protein. The exact nature of the etiological agent or the prion protein is thought to be a misfolded protein. Although current research has provided a wealth of data indicating that a structural isoform of the prion protein is the responsible pathogen, this hypothesis is not yet experimentally proven.
AD Laboratory of Neurobiology, Born Bunge Foundation, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerp, Belgium.
SP englisch
PO USA