NR ALZE
AU Vargas,M.E.; Kupersmith,M.J.; Savino,P.J.; Petito,F.; Frohman,L.P.; Warren,F.A.
TI Homonymous field defect as the first manifestation of Creutzfeldt-Jakob disease
QU American Journal of Ophthalmology 1995 Apr; 119(4): 497-504
PT journal article
AB PURPOSE: Although in the early stage of Creutzfeldt-Jakob disease most patients have obvious dementia, we found that the disease can be diagnosed in patients solely on the basis of a visual system disorder. METHODS: We examined three patients who initially complained of a nonspecific, insidious visual disturbance. RESULTS: The three patients were found to have Creutzfeldt-Jakob disease, confirmed by histopathologic analysis. Each patient had a homonymous hemianopsia on the first neuro-ophthalmologic examination. The initial neurologic, neuroimaging, and electrophysiologic examinations were not conclusive. The subsequent rapid deterioration in the neurologic status, including dementia and typical electroencephalographic changes, was suggestive of Creutzfeldt-Jakob disease. CONCLUSION: At onset of Creutzfeldt-Jakob disease, patients may have a homonymous hemianopsia despite normal results of magnetic resonance imaging of the brain and neurologic examination.
IN Als frühes Symptom der Creutzfeldt-Jakob-Krankheit bei 3 PatientInnen fiel eine gleichseitige Halbseitenblindheit auf.
ZR 32
MH Aged; Biopsy; Brain/pathology; Case Report; Creutzfeldt-Jakob Syndrome/complications/*diagnosis; Electroencephalography; Hemianopsia/*diagnosis/etiology; Human; Male; Middle Age; Perimetry; Support, Non-U.S. Gov't; *Visual Fields
AD Department of Ophthalmology, New York University Medical Center, New York, USA
SP englisch
PO USA