NR ALZW
AU Verevka,S.V.
TI Prions and protein inhibitors of proteinases: structural analogies and their consequences. III. Additive risk factor in transgenic technologies.
QU Ukrainskii Biokhimicheskii Zhurnal 2001 Jan-Feb; 73(1): 153-4
PT journal article; review; review, tutorial
AB The article presents the risk factor connected with transgenous technologies. The probable risk is stipulated by a possibility to produce the proteins capable to initiate prion-conditioned neurodegenerative processes as a consequence of possible membrane folding of the recombinant protein portion.
ZR 13
MH Animal; Mice; Mice, Transgenic; PrPsc Proteins/*chemistry; Protease Inhibitors/*chemistry; Protein Conformation; Risk Factors
AD Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. verevka@biochem.kiev.ua
SP englisch
PO Ukraine