NR ALZY
AU Verevka,S.V.
TI [Prions and serpins: structural analogs and their consequences. I. Protease-transport hypothesis]
OT Priony i serpiny: strukturnye analogii i ikh sledstviia. I. Proteinazo-transportnaia gipoteza.
QU Ukrainskii Biokhimicheskii Zhurnal 1999 Sep-Oct; 71(5): 135-9
PT journal article
AB The structural analogy between prions pathogenic form and serine proteinase inhibitors (serpins) was laid into the basis of explaining the prion diseases main peculiarities - nucleic-acid-free transfer of infection, neurodegenerative processes, existence of the minimal infective dose, long-term latent period and some others. The assumption about pathogenic prions as the proteins supplying the extracellular proteinases transport into the intracellular space permits to bring the pathogenesis of prion diseases to the known and partially proved processes order regarding the case of prion diseases.
MH English Abstract; Models, Molecular; Prion Diseases/pathology/transmission; Prions/*chemistry; Protein Conformation; Serpins/*chemistry
AD A.V. Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
SP russisch
PO Ukraine