NR AMDG
AU Wade,W.F.; Dees,C.; German,T.L.; Marsh,R.F.
TI Immunochemical characterization of proteins from scrapie-infected hamster brain, using immunoblot analysis
QU American Journal of Veterinary Research 1987 Jul; 48(7): 1077-81
PT journal article
AB Preparations of brain plasma membrane from scrapie-infected or noninfected hamsters were extracted with a solvent and were used to inoculate rabbits. Antisera evaluated by immunoblot analysis revealed a protein of 45 kD in scrapie-infected hamster brain that had a greater signal compared with proteins of comparable relative mass in noninfected brain. This 45-kD protein was not increased in scrapie-infected mouse, sheep, or goat brain. Seemingly, the 45-kD protein may be a degradation product of glial fibrillary acidic protein.
MH Animal; *Brain Chemistry; Brain Diseases/*microbiology; Hamsters; Immunoassay; Male; Nerve Tissue Proteins/analysis/*immunology; Prions/*immunology; Scrapie/*immunology; Support, Non-U.S. Gov't; Viral Proteins/analysis/*immunology
SP englisch
PO USA