NR AMEC
AU Walis,A.; Liberski,P.P.; Brown,P.; Gajdusek,D.C.
TI Electron microscopic studies of the optic nerve in experimental scrapie and the panencephalopathic type of Creutzfeldt-Jakob disease
QU Folia Neuropathologica 1997; 35(4): 255-8
PT journal article
AB We report the optic nerve ultrastructural pathology in experimental scrapie and Creutzfeldt-Jakob disease. Vacuoles developed within myelinated axons contained typical secondary vacuoles and curled membranes. These were seen either within the axoplasm or within the myelin sheath which split either at the major dense line or at the intraperiod line. Spongiform changes were accompanied by an exuberant cellular reaction consisting of macrophages and hypertrophic astrocytes. Occasionally, vesicular myelin degeneration and coated vesicles in a close proximity to the myelin were observed.
MH Animal; Astrocytes/ultrastructure; Creutzfeldt-Jakob Syndrome/*pathology; Hamsters; Mesocricetus; Mice; Optic Nerve/*ultrastructure; Scrapie/*pathology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Vacuoles/ultrastructure
AD Department of Oncology, School of Medicine, Lodz, Poland.
SP englisch
PO Polen