NR AMIS
AU Weissmann,C.
TI A 'unified theory' of prion propagation
QU Nature 1991 Aug 22; 352(6337): 679-83
KI Nature. 1991 Nov 7;354(6348):25-6. PMID: 1944567
PT journal article; review; review, academic
AB There is now very persuasive evidence that the transmissible agent for spongiform encephalopathies such as scrapie, consists of a modified form of the normal host protein PrPc, devoid of any nucleic acid. On the other hand, because there are many different strains of scrapie agent with distinct phenotypes which can be propagated in animals homozygous for the PrPc gene, it has been suggested that a nucleic acid must be a component of the agent. Can the two views be reconciled?
ZR 149
MH Animal; Creutzfeldt-Jakob Syndrome/transmission; Human; Nucleic Acids/physiology; Prions/analysis/genetics/*pathogenicity; Scrapie/transmission; Slow Virus Diseases/genetics/*transmission
AD Prof. Charles Weissmann, Universität Zürich, Institut für Molekularbiologie, Abteilung I, Hönggerberg, 8093 Zürich, Schweiz, Postfach, Tel. 633 24 91, Fax 371 72 05
SP englisch
PO England