NR AMJX
AU Westaway,D.; Carlson,G.A.; Prusiner,S.B.
TI On safari with PrP: prion diseases of animals.
QU Trends in Microbiology 1995 Apr; 3(4): 141-7
PT journal article; review; review, tutorial
AB Prions are infectious pathogens that cause fatal neurodegeneration in humans and animals and are composed largely, or entirely, of an aberrant isoform of the host-encoded prion protein (PrP). A post-translational process involving a conformational change in PrP is a significant feature of their replication. Differences in PrP sequences modify the incubation times, neuropathology and properties of prion 'strains'.
ZR 84
MH Animal; PrPc Proteins/genetics/metabolism; PrPsc Proteins/genetics/metabolism; *Prion Diseases/diagnosis/epidemiology/prevention & control; *Prions/classification/genetics/pathogenicity; Scrapie/genetics; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.
AD Dept of Neurology, University of California, San Francisco 94143, USA
SP englisch
PO England