NR AMKB
AU Westaway,D.; Mirenda,C.A.; Foster,D.B.; Zebarjadian,Y.; Scott,M.R.D.; Torchia,M.; Yang,S.L.; Serban,H.; DeArmond,S.J.; Ebeling,C.; Prusiner,S.B.; Carlson,G.A.
TI Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice
QU Neuron 1991 Jul; 7(1): 59-68
PT journal article
AB Prolonged incubation times for experimental scrapie in I/LnJ mice are dictated by a dominant gene linked to the prion protein gene (Prn-p). Transgenic mice were analyzed to discriminate between an effect of the I/LnJ Prn-pb allele and a distinct incubation time locus designated Prn-i. Paradoxically, 4 independent Prn-pb transgenic mouse lines had scrapie incubation times shorter than nontransgenic controls, instead of the anticipated prolonged incubation periods. Aberrant or overexpression of the Prn-pb transgenes may dictate abbreviated incubation times, masking genuine Prn-p/Prn-i congruence; alternatively, a discrete Prn-i gene lies adjacent to Prn-p.
MH Animal; Brain/metabolism; *Gene Expression; Mice; Mice, Transgenic; PrPsc Proteins; Prions/genetics/metabolism; RNA, Messenger/metabolism; Scrapie/*physiopathology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Time Factors; Viral Proteins/*genetics/metabolism
AD Department of Neurology, University of California, San Francisco 94143
SP englisch
PO USA