NR AMLM
AU Wickner,R.B.; Taylor,K.L.; Edskes,H.K.; Maddelein,M.L.
TI Prions: Portable prion domains.
QU Current Biology 2000 May 4; 10(9): R335-7
PT journal article; review; review, tutorial
AB Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.
ZR 36
MH Animal; Binding Sites; Fungal Proteins/*metabolism; Prions/*metabolism; Saccharomyces cerevisiae/metabolism
AD Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, 20892-0830, USA. wickner@helix.nih.gov
SP englisch
PO England