NR AMMH
AU Wierzba,W.; Wajgt,A.
TI [Importance of genetic factors in pathogenesis of subacute spongiform viral encephalitis]
OT Znaczenie czynnikow genetycznych w patogenezie podostrych transmisyjnych encefalopatii gabczastych
QU Postepy Higieny I Medycyny Doswiadczalnej 1995; 49(2): 253-61
PT journal article; review; review, tutorial
AB Recently there has been achieved a substantial progress in research concerning pathogenesis of subacute spongiform viral encephalopathies. For this group of disorders, there has been found a common unconventional virus - proteinaceous infectious particle (PrP). There has been recognised a molecular mass, biochemical composition and physicochemical properties of this infectious form. Mutations of scrapie amyloid precursor gene discovered in Gerstmann-Sträussler-Scheinker syndrome (GSS) and familial cases of Creutzfeldt-Jakob disease (CJD) have been revealed. Nowadays examinations in the field of relationships between prion protein and mutations of scrapie precursor gene are continued.
ZR 22
MH Creutzfeldt-Jakob Syndrome/genetics; English Abstract; Gerstmann-Sträussler-Scheinker Disease/genetics; Human; Mutation; PrPc Proteins/genetics; Prion Diseases/*genetics
AD I Klinika Neurologii Slaskiej Akademii Medycznej w Katowicach.
SP polnisch
PO Polen