NR AMOY
AU Williams,A.E.; Ryder,S.; Blakemore,W.F.
TI Monocyte recruitment into the scrapie-affected brain
QU Acta Neuropathologica 1995; 90(2): 164-9
PT journal article
AB The recruitment of monocytes into the scrapie-affected brain was investigated in female mice reconstituted with male bone marrow, using a Y-chromosome-specific probe and F4/80 immunocytochemistry. Recruitment of monocytes could be demonstrated in six out of eight animals and the number of recruited cells correlated with the severity of vacuolation in most, but not all, animals. The proportion of microglia derived from recruited monocytes varied between individual animals, did not correlate with the increase in cellularity (glia) in affected areas of brain and did not affect the length of incubation period. Thus, it is unlikely that the recruitment of monocytes is a pivotal event in the development of early pathological changes in scrapie. The morphology of recruited cells in scrapie lesions, as revealed by F4/80 immunoreactivity, was indistinguishable from that of activated resident microglia.
IN Die Zuwanderung von Monozyten in die Gehirne Scrapie-infizierter Mäuse korrelierte in den meisten, aber nicht allen Tieren mit dem Ausmaß der Durchlöcherung.
ZR 27
MH Animal; Central Nervous System/*pathology; Female; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Monocytes/*metabolism; Scrapie/*pathology; Support, Non-U.S. Gov't; Thalamus/*pathology
AD Institute for Animal Health, BBSRC and MRC Neuropathogenesis Unit, Edinburgh, UK
SP englisch
PO Deutschland