NR AMRF
AU Wisniewski,H.M.; Moretz,R.C.; Lossinsky,A.S.
TI Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent
QU Annals of Neurology 1981 Dec; 10(6): 517-22
PT journal article
AB Mice inoculated intracerebrally with mouse brain homogenate infected with a particular strain of scrapie agent developed amyloid and neuritic plaques and amyloid tubercles along the injection track, solid wall-like infiltrations at the injection site, or both. Our observations implicate an infections agent in the localized formation of the amyloid and the neuritic plaque - the leading pathological change found in normal elderly people and animals and in patients with senile dementia of the Alzheimer type. Further, these studies indicate that microglia appear to play a central role in the pathogenesis of amyloid formation and could be involved in the processing, production, and assembly of the fibers.
MH Amyloidosis/*pathology; Animal; Brain/*pathology; Calcinosis/pathology; Female; Male; Microscopy, Electron; Muridae; Nerve Degeneration; Nerve Fibers/ultrastructure; Neurofibrils/ultrastructure; Neuroglia/ultrastructure; Neurons/ultrastructure; Phagocytes/ultrastructure; Scrapie/*pathology; Sheep
SP englisch
PO USA