NR AMRG
AU Wisniewski,H.M.; Bruce,M.E.; Fraser,H.
TI Infectious etiology of neuritic (senile) plaques in mice
QU Science 1975 Dec 12; 190(4219): 1108-10
PT journal article
AB Brains of inbred female VM mice infected with scrapie agent were studied with the use of the Bodian silver impregnation method and by electron microscopy. In brains affected with scrapie, after an incubation period of between 587 and 655 days, numerous primitive, classical, and amyloid plaques were found. No plaques of any type were seen in the control mice.
MH Amyloid/metabolism; Animal; Brain/metabolism/*pathology; Dementia/pathology; Female; Human; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurons/pathology/ultrastructure; Scrapie/metabolism/*pathology; Sheep
SP englisch
PO USA